What Is EZH2 Antibody?

EZH2 (histone-lysine N-methyltransferase) is part of the Polycomb-group (PcG) families. Members of the family make multimeric protein complexes that are responsible for maintaining the transcriptional repressive condition of genes through many generations of cells. The protein is associated with the embryonic ectoderm developmental protein as well as the VAV1 oncoprotein and the nuclear protein X-linked.

EZH2 could play a function in the hematopoietic or the central nervous system. Genetic mutations that affect EZH2 could result in Weaver syndrome (WVS). EZH2 (Enhancer of Zeste homolog 2) is a human homolog of the Drosophila polycomb-group enhancer protein of the Zeste protein. You can also know more about EZH2 antibodies-online via https://www.bosterbio.com/anti-kmt6-ezh2-picoband-trade-antibody-a00050-1-boster.html.

It is a SET-like domain that catalyzes methylation of histone H3 in Lysine 27. Polycomb-group proteins inhibit the expression of genes by binding to chromatin, and then locally altering the structure of chromatin. EZH2 BMI-1, EZH2 as well as Suz12 are found in both the PRC2 as well as PRC3 protein complexes, which function to act as epigenetic mediators silencing.

EZH2 connects to the embryonic ectoderm developmental protein and the VAV1 Oncoprotein and the nuclear protein X-linked. EZH2 could play a function in the hematopoietic as well as the central nervous system. The deregulation of EZH2 can be linked to various cancers.

The enhancer of zeste homolog 2 (Ezh2) is a member of the large family of proteins is composed of four regions that are conserved, including domain I, Domain II and a cysteine-rich amino acid stretch that is located prior to the carboxy-terminal domain of SET. The SET domain is associated with the histone methyltransferase (HMTase) activation.

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