Posts Tagged ‘Calnexin antibody’

All You Need to Know About Calnexin Antibody

Friday, January 29th, 2021

Calnexin Antibody is a high-quality monoclonal which is used for the detection of the protein named Calnexin in mouse, rat, and humans. Calnexin Antibody is available as both the non-conjugated anti-Calnexin antibody and multiple conjugated anti-Calnexin antibodies.

Calnexin and Calregulin are the two calcium linked proteins that are local to the endoplasmic reticulum. Calnexin is local to the membrane and Calregulin to the lumen. You can buy a high-quality calnexin antibody at


Calnexin is a type I membrane protein that communicates with newly synthesized glycoproteins present locally in the endoplasmic reticulum or ER. It helps in assembling the protein and in retaining unassembled proteins inside the ER. Calregulin has both low and high-affinity calcium-linking sites.

Both Calnexin and Calregulin do not contain the calcium-binding “E-F hand” motif which can be found in calmodulins. Both, Calnexin and Calregulin are important for the maturation of glycoproteins present inside the endoplasmic reticulum and can bind many of the same proteins.

So, calnexin is a calcium-bound protein embedded inside the ER membrane that is used to hold the freshly synthesized glycoproteins present inside the ER to ensure their proper folding and quality control. The specifics of Calnexin for a subset of glycoproteins is defined by a lectin site, which links an early oligosaccharide which intermediates on the folding glycoprotein.